Gene editing has been proved powerful to generate animal models for studying brain diseases. The ability of the gene-editing to target genome in any type of cells allows for modeling brain diseases directly to the brain. Focused on psychiatric disorders research, Creative Biolabs has been committed to psychiatric animal model development for years and thus accumulated extensive experience in gene editing strategies. With advanced technology and mature researchers, we are capable of providing global customers with satisfying gene editing animal model development services.
Importance of Gene Editing Animal Models in Psychiatric
Neurological disorders are diseases of the central and peripheral nervous systems. Common neurological disorders in the brain include autism, epilepsy, schizophrenia, dementia-related diseases like Alzheimer's and Parkinson's, and brain tumor. Although the generation of animal models of such neurological disorders has long been a focus of basic and translational researches, effective therapeutic intervention is still lacking for most neurological disorders. Therefore, further sophisticated disease models would be a prerequisite for facilitating molecular and mechanistic studies on these diseases followed by knowledge translation into clinical benefits for patients. A number of genetic mutations are known to cause neurological disorders. Thus, identification of the genetic mutations in these diseases has enabled the generation of a variety of animal models via genome modifications.
Gene Editing in Animal Models
An approach, editing genes in zygotes to generate live animals, will carry genetically modified genes in their brain tissues. The resulting animals carry the genetically modified genes in different types of cells, including neuronal cells in the brain, derived from the early embryos. This approach has been used successfully to generate small animal models, including zebrafish, flies, frogs, mice, rats, and rabbits. Since the genetic mutations created occur at the one-cell stage or early embryos, this approach is believed to generate genetic mutations similar to those genetic defects in humans.
Although genetically modified animal models have been widely used to investigate the mechanisms of different brain disorders and to develop therapeutic strategies, the ways to produce animal models determine the nature of the disease models and their utility for different purposes. In general, genetically modified animal models can be classified as transgenic or gene-targeted animal models. In transgenic models, the transgene is randomly inserted into the genome as an exogenous gene and is expressed under the exogenous promoter. In gene-targeted animal models, the specific locus or region of an endogenous gene is altered to mimic a specific genetic mutation in humans. Obviously, gene-targeted (knock-in or knockout) animal models are intended to recapitulate the same genetic defects seen in human beings and are expected to more faithfully replicate patient pathology.
Services at Creative Biolabs
Committed to psychiatric disorders research for years, Creative Biolabs has established a comprehensive platform with the latest technologies and mature technicians in psychiatric animal models development. Our professional scientists with advanced degrees will assure the quality of the services and the optimal services system will assure the customers’ experience.
Gene editing animal models have become a novel and necessary approach in psychiatric disorder research. With extensive professional experience accumulated from practice, Creative Biolabs offers high-quality gene editing animal model development services to global researchers. If you have any other questions, please feel free to contact us for more information.
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