Animal models offer heuristic research tools to understand the causes of human diseases and to identify potential treatments. With rapidly evolving genetic engineering technologies, mutations identified in a human disorder can be generated in the animal genome. Based on our advanced technique platforms, Creative Biolabs help you construct genetic modulation in the non-mammalian model or rodent/nonhuman primate (NHP) for drug target validation.
Background of Genetically Engineered Models in Target Validation
Animal models of human diseases are widely used in biomedical research. Among the diseases affecting the brain, psychiatric disorders have attracted special attention due to their high prevalence and significant clinical features. Due to the multifactorial origin, high heterogeneity, and symptoms (such as hallucinations and delusions) of psychiatric disorders, many difficulties need to be overcome to find a good animal model of psychiatric disorders, which can not be evaluated by ordinary experimental animal models. Using animal models to replicate at least some specific traits that can be studied individually, known as endophenotype, is often reported. Therefore, the use of genetic engineering methods to modify animal models is considered to be an excellent research tool for psychiatric target validation.
Genetically Engineered Animal Models in Creative Biolabs
In vivo research is an important tool for the identification and validation of novel drug targets in medicine. Animal studies in target validation studies require the selected target or compound to meet the requirements of species specificity and target specificity. Currently, Creative Biolabs provides different genetically engineered animal models to assist in the validation of psychiatric targets.
In invertebrate models, due to the high conservation, low complexity of important pathways, and shorter life cycle compared to mammals, they can perform a variety of methods to induce changes in the endophenotype of interest.
For target validation studies, small rodents remain the first choice. Mice are the preferred species when genetically engineered technology (such as gene knockout) is in use. In addition, given the phylogenetic gap between humans and rodents, which translates to considerable differences in physiology and behavioral profiles, NHPs stand as the most appropriate animal models for several psychiatric symptoms.
Services in Creative Biolabs
Fuelled by the genomics revolution, pharmaceutical and biotechnology companies are blessed with an unprecedented wealth of potential drug targets. Irrespective of whether a system or a molecular approach is chosen (starting from patients or animal models and clinical or cell samples, respectively), the drug discovery process entails validating targets in both cell and animal models. Creative Biolabs provides a variety of genetically engineered animal models for target validation and qualification. If you have any questions, please contact us.
For Research Use Only.
