Target identification and validation are the first key stages in the drug discovery pipeline. Therefore, researchers are necessarily concerned with this initial aspect of the drug discovery process. As a global-leading company focusing on novel psychotropic drug development, Creative Biolabs has established a comprehensive platform with an optimal service system to provide target validation and qualification services.
Target Validation in Pharmacology
The challenges facing central nervous system (CNS) drug discovery are multifactorial and are apparent across the value chain of the discovery and development process. The conventional process of drug discovery and development starts with target identification and is followed by increasing efforts to validate the target, along with the application of medicinal chemistry and associated disciplines to optimize the properties of potential drug molecules. Validation in pharmacology is one of the three crucial components (pharmacology, genetically engineered models, and translational endpoints) of target validation and qualification in preclinical data.
Target Validation and Qualification in Pharmacology
Correct identification and validation of drug-target interactions is the first step in the drug discovery pipeline. Until now, there are many potential drug-target interactions that have not been discovered. The identification of novel drugs and their targets is still an extremely difficult goal owing to the relatively limited knowledge about the complex relationship between chemical space and genomic space. There are many factors that affect the establishment of the interactions between a drug and its targets, such as various chemical bonds that are related to the affinity of the drug for its targets.
After confirming target protein is expressed or active in the desired organ/subregion/cell types, validate if target RNA expression is altered by the disease is an important step. Compared with protein expression validation, RNA expression validation is more efficient and fast.
The majority of drug targets are cellular proteins, which aim to treat or diagnose a disease by selectively interacting with chemical compounds. Current studies have shown that classical therapeutic drug targets contain 130 protein families, such as enzymes, G-protein-coupled receptors (GPCRs), ion channels and transporters, nuclear hormone receptors.
Services at Creative Biolabs
Creative Biolabs has focused on psychotropic drug development for years, and thus has accomplished a lot of relative projects including hundreds of customer-satisfied services. With such extensive experience accumulated from practice, we are capable of providing reliable and high-quality target validation and qualification services to global clients.
Why Us?
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Professional: Ph.D. level experts specialized in drug development for years.
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Reliable: Hundreds of successful precedents and great industry reputation.
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Top-rated customer experience: High-quality services with competitive prices.
Validation and qualification in pharmacology is usually the first step of target validation. Considering its importance, Creative Biolabs has developed a professional and comprehensive platform with the latest technologies and mature technicians to assure the quality of our services. If you are interested in the target validation and qualification, please feel free to contact us for more information.
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