Introduction to the Central Nervous System (CNS)
The Central Nervous System (CNS) includes the brain and the spinal cord. The brain is protected by the skull (the cranial cavity) and the spinal cord travels from the back of the brain, down the center of the spine, stopping in the lumbar region of the lower back. CNS is made up of vast neural networks, signaling within these circuits enables thinking, language, feeling, learning, memory, and all function and sensation. Creative Biolabs provides high-quality systematic CNS transport analysis services.
Types and Functions of Transport Systems in the CNS
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Receptor-Mediated Transport
Receptor-mediated transport systems work via endosomal structures in which substances in the extracellular space (ECS) or cerebrospinal fluid (CSF) are taken up by energy-requiring systems into endosomal sacks and then transported from the ECS to the inside of cells or in the reverse direction.
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Active Transport and Facilitated Diffusion
Epithelial cells must transport substances through two plasma membranes for through-put transport. The transport mechanism into the epithelial or endothelial cell from the blood side may be via active transport and from the other (apical) side facilitated diffusion.
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Carrier-Mediated Transport
Different types of carrier-mediated transport systems exist in plasma membranes and/or in other parts of the cell. There are at least three cyclic organic acid transport systems at the blood-brain barrier (BBB) and/or blood CSF barrier. With the help of a glucose carrier, Dehydroascorbic acid (DHA) can be transferred readily from the blood into the brain via cerebral capillaries.
The P-Gp system is involved in transferring certain drugs back into the blood after they have entered endothelial cells (from the blood).
What We Can Provide?
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Systematic Analysis of CNS Transport
CNS is a vital part of the human body that coordinates the actions by transmitting signals. Because of the existence of the BBB and the blood-spinal cord barrier, diseases in CNS can hardly be directly intervened by non-invasive methods. To better understand the way in which molecules are transported within the central nervous system, we offer a series of services about systematic analysis of CNS transport from different aspects:
We can not only design a reasonable test scheme and give you professional guidance, but also provide you the most unique service. Our scientists are willing to communicate the details of the project with you and give the most satisfactory service.
Creative Biolabs keeps working hard to provide first-class services to customers all over the world. Our scientists have helped millions of confused researchers to solve their problems. The development of psychotropic drugs is a great challenge. As the leader of the industry, we have the ability and responsibility to face this problem together with you. If you have any questions, please contact us.
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