The most common way to develop animal models is to use drug therapy or "drug-induced state" to produce psychotic-like symptoms in non-psychotic patients. These models usually have certain predictive or structural validity, and play an important role in establishing the three most prominent theories of psychiatric disorders: dopamine hypothesis, serotonin (or serotonin dopamine) hypothesis and glutamate hypothesis.
Background of Drug-Induced Models in Psychiatric Disorders
There are many reasons to use animal models when studying diseases that affect the brain. Unclear understanding of the etiology and pathophysiology of psychosis has led to an unmet clinical need for better drug treatments. Therefore, there is a need for a good model to clarify the neurobiology involved in psychiatric disorders, and to identify biomarkers that can help diagnose and/or develop new therapies. There is no evidence in animal experiments to prove that it is impractical to advance in clinical trials of novel drugs that have only been tested in cell models. Experiments have proved the value of animal models for drug development. The use of drug-induced psychosis animal models helps to better understand the pathogenesis and treatment of psychiatric disorders.
Operational Strategies of Drug-Induced Models
The most widely studied class of drug-induced models of psychiatric disorders is based on the behavioral effects of psychostimulant drugs. Therefore, the animal models of drug-induced psychosis mainly include the following three types:
What Can We Do?
With years of experience in the industry of preclinical models and excellent professional skills, Creative Biolabs is proud to help you identify the most appropriate models for your psychotic research. And you can also explore our extensive and broad-based library of models to find the one you need. For more detailed information, please feel free to contact us or directly sent us an inquiry.
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