Proteomics is a large-scale comprehensive study of protein abundances, the variations, modifications, and their interacting partners and networks. Creative Biolabs is a recognized world leader in the development of innovative next-generation proteomics workflows for human diseases. By combining our cutting-edge proteomics expertise with your psychiatric disease research, Creative Biolabs can help to reveal a deeper understanding of biology and to provide actionable knowledge and confidence to your project. No matter what stage of your research, our discovery and targeted proteomics will give you the key functional insights you need to move forwards.
Proteomics
Proteomics is a research field aiming to characterize molecular and cellular dynamics in protein expression and function on a genome-wide scale and its application in psychiatric research is relatively new. It represents the effort to establish the identities, quantities, structures, and biochemical and cellular functions of all proteins in an organism, organ, or organelle, and how these properties vary in space, time, or physiological state.
Proteomic Studies of Psychiatry Disorders
Proteomic studies, by testing large numbers of proteins for associations with one specific psychiatry disease, may contribute to the understanding of the molecular mechanisms of the disease. It indicates the types and locations of cells most likely to harbor pathological alterations and provides a molecular vision of the disease that supports the acquisition of new knowledge about its biochemical pathways and the identification of potential biomarkers.
Case 1: Schizophrenia
As a multifaceted disease, schizophrenia involves changes in protein expression, thus also affecting protein networks and signal pathways. These alterations can be detected by proteomic analyses performed on peripheral samples such as plasma. Proteomic studies are important for the comprehension of molecular mechanism of Schizophrenia and numerous studies have been published to identify some specific biomarkers to be of aid in the diagnosis and treatment of Schizophrenia. Proteomic studies have been carried out with different approaches such as two-dimensional gel electrophoresis/mass spectrometry (2DE/MS), LC-MS/MS, surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) and reverse-phase high-performance liquid chromatography electrospray ionization tandem mass spectrometry (RP-HPLC-ESI-MS). In conclusion, the results obtained in these proteomic studies suggest that a panel of biomarkers is required for early detection of schizophrenia and evaluation of therapy efficacy.
Case 2: Bipolar Disorder
Bipolar disorder (BD) is a severe neuropsychiatric disorder of mood characterized by a recurrent disruptive episode of mania, depression and mixed states alternating by periods of euthymic moods. Promising proteomic analytical strategies have been proposed to develop signature biomarkers. Gel-based/ Gel-free approaches using high-resolution mass spectrometry-based platforms have been used to define BD proteome. Studies on BD proteome mainly focus on post-mortem tissues, biological fluid and blood cell samples. What’s more, the results from proteomic studies suggest a different expression of proteins involved in energy production, glucose metabolism and mitochondrial function.
Case 3: Major Depression
Major depression (MD) is a severe, systemic and multifactorial disorder with a high incidence in the population. Until now, there is a lack of clinically validated lab-based tests to aid in the diagnosis of MD. For this reason, proteomic approaches can provide useful contributions to the investigation of the molecular biology of MD and the identification of biomarkers could help diagnosing MD or predicting treatment response. The design of proteomic studies includes experiments performed by comparing the different areas of human brain tissues and biological fluids from depressive patients and controls. Besides, studies carried out in MD animal models are needed.
What Can We Do for You?
Creative Biolabs uses deep proteomic techniques to offer our clients the following proteomics services.
High-quality proteomics data analysis will open a new pathway for disease diagnosis and treatment to promote your psychiatric disease research. Our expert team is glad to support you in identifying the most suitable proteomics workflow and study design to best address your research question. Contact us to discuss your specific study needs with our scientists and technical consultants.
For Research Use Only.
