Brain imaging, also called neuroimaging, is being increasingly used to help detect and diagnose a number of medical disorders and illnesses. Currently, the main use of brain scans for mental disorders is in research studies to learn more about the disorders. Brain imaging now is commonly used to diagnose neurological and psychiatric diseases. Creative Biolabs provides various brain imaging techniques to global customers to promote psychiatric disease research.
Importance of Brain Imaging Technique
The past several decades have seen the widespread adoption of advanced brain imaging techniques for the routine clinical assessment of brain tumors. The incorporation of these biology-driven brain imaging methods has been indispensable to the neurosurgeon and contributed to improved diagnosis, surgical and radio surgical planning, and assessment of treatment response. Neuroimaging will continue to evolve to reflect our growing understanding of various psychiatric diseases.
Brain Imaging Techniques
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Magnetic Resonance Imaging (MRI)
MRI is a non-invasive neuroimaging technique that has been used to identify the structural and functional brain substrates and pathologies associated with human locomotion in a number of neurological conditions - including Parkinson’s disease (PD), stroke, Alzheimer’s disease, related dementias (ADRD), and multiple sclerosis (MS). Standard three-dimensional structural images have been used to link locomotion in neurological conditions to brain volume or atrophy in a particular brain region, or a set of regions. Functional MRI (fMRI) has been used to linked functional activation of a brain region, or a set of brain regions, during imagined (or motor imagery of) locomotion, as well as to functional connectivity during rest (resting-state fMRI).
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Molecular imaging methods
Molecular imaging methods include positron emission tomography (PET) and single-photon emission computed tomography (SPECT), which can image the brain during actual and during mental imagery of gait. Some studies have also correlated PET or SPECT imaging results with gait performance. These imaging techniques use radiolabeled ligands that interact in vivo with the biological processes (i.e., neurotransmitter receptors for the DAT-Scan, amyloid deposition for the Pittsburgh compound B-PiB-PET); measure brain metabolism (i.e., fludeoxyglucose-FDG PET), or the cerebral blood flow (i.e.; SPECT). The molecular imaging studies including patients with neurological conditions have mainly focused on patients with parkinsonism or dementia.
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Functional near-infrared spectroscopy (fNIRS)
fNIRS is a portable non-invasive optical imaging method. Similar to functional MRI that measures the blood oxygenation level-dependent (BOLD) signal of neural activity - an estimation of variation of deoxy-hemoglobin concentrations - fNIRS uses the light-tissue interaction (within the near-infrared spectrum) to measure the changes in cortical oxygenation. The main advantage of the fNIRS technique for studying gait control relies on its portable nature to allow measurement of brain activity during real walking; however, its low spatial resolution (only a few centimeters under the skull) represents its main limitation.
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Electroencephalography (EEG)
EEG is another non-invasive brain imaging modality with fNIRS that allows studying cortical activation with a high degree of precision in time (1 ms). One of the strengths of EEG is the possibility to assess brain functioning during online walking and to correlate brain functioning with gait measures.
Services at Creative Biolabs
With years of experience in psychotropic drug development, Creative Biolabs has established a comprehensive system and technology platform in brain imaging services. We provide not only high-quality technology services mentioned above (including MRI, fMRI. SPECT, fNIRS, and EEG) but also other advanced techniques such as micro-CT (in vivo or in vitro) and micro-PET. With an excellent expert team, we are capable of providing both a stand-alone service or integrated projects.
Advantages
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Team of Ph.D. level scientists
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Industry-leading technology platform
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Reliability and information security
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Accurate, efficient, and cost-effective
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Perfect after-sales service
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