Creative Biolabs is a dedicated psychotropic drug development provider that strives to provide the best service. We have more than ten years of experience in generating, characterizing psychotropic targets, and applying them for our global customers' drug development projects. Currently, our scientists could offer neurotensin (NT) antagonist development services to meet our customers' specific demands.
NT is a 13 amino acid regulatory peptide found mainly in the gut and brain and has been implicated in controlling blood pressure, pain, appetite, and body temperature. It behaves as a neuromodulator to several neurotransmitter systems and has a close anatomical and functional relationship with the mesocorticolimbic and dopamine system. The effects of NT are mediated by two G protein-coupled seven-transmembrane domain receptors (NTR1 and NTR2) and a type I amino acid receptor (NTR3). Due to its association with such a wide variety of neurotransmitters, NT is implicated in the pathophysiology of several CNS disorders such as schizophrenia, drug abuse, Parkinson's disease (PD), pain, central control of blood pressure, eating disorders, as well as, cancer and inflammation.
NT Antagonist with Psychiatric Disorders
Due to the close association of NT with dopaminergic neurons and its neuromodulatory effects on the dopaminergic system, NT has been implicated in the pathophysiology of major mental disorders such as schizophrenia, drug abuse, and autism. Thus, NT antagonists might be considered as a good tool for investigating the pathophysiological role of NT in psychiatric diseases. Although the behavioral effects of NT antagonist administration remain to be examined in paradigms relevant to antipsychotic drug activity, NT antagonist can be an interesting option for the treatment of schizophrenia and tardive dyskinesia based on the property of the NT system and preclinical data.
NT Antagonist Development at Creative Biolabs
NT system has a potential role in managing major mental disorders with a special focus on schizophrenia, substance abuse, and autism. Moreover, the NT antagonist has become an attractive therapeutic target for the treatment of psychiatric disorders due to the rapid advances in understanding the structure and regulation of the NT system. To meet the needs of specific drug discovery projects, Creative Biolabs provides customized NT antagonist development services. Moreover, we adapt our manufacturing capacities and corresponding costs to your needs depending on your current development phase. We provide full technical support and will never leave you with an unresolved issue.
As a leading CRO for psychotropic drug development, Creative Biolabs is the premier provider of services for global customers. Our approach is based on our procedural building blocks that allow customization of any service request according to your specific needs. If you are interested in learning more about our solutions, please do not hesitate to contact us.
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