With the commitment of being your best psychotropic drug development partner, Creative Biolabs is capable of providing our clients with a variety of customized serotonin (5-hydroxytryptamine, 5-HT) receptor antagonist discovery services. Equipped with a team of professional scientists, we have won a good reputation among our worldwide customers for accomplishing numerous challenging projects in this field. In our company, our scientists specialized in various 5-HT receptors studies will work with you to develop the most appropriate strategy that will offer reproducible data for your research.
Introduction to 5-HT Receptor
5-HT receptors are a class of protein-coupled receptors that play an important role in neurotransmitter 5-HT-mediated signal transduction. 5-HT receptors can be divided into seven subtypes, 5-HT1 to 5-HT7. These receptors are usually be found in the brain, sensory organs, and peripheral nerves. Most 5-HT receptors are postsynaptic receptors, but 5-HT1A and 5-HT1B, which are primarily presynaptic receptors, regulate the release of serotonin.
Pilot studies have indicated that 5-HT receptors are also associated with many neurological and physiological processes. As a result, 5-HT receptors have been considered as perfect targets for the treatment of numerous psychiatric disorders. Recently, many attempts have been made to investigate the characteristics of 5-HT receptor second messenger systems, the diversity of related pathways, as well as these pathways-based pathogenic mechanisms and disease treatment. Up to now, a wide variety of 5-HT antagonists, such as dolasetron, granisetron, and palonosetron, have been generated as common drugs to inhibit the function of 5-HT receptors.
5-HT Receptor Antagonist Discovery Services for Psychiatric Diseases
5-HT receptor antagonists are a group of drugs that are broadly used for the treatment of nausea and vomiting caused by cancer chemotherapy and radiation therapy. Recent studies have shown that genetic mutations occurred in the 5-HT signaling and its receptors, including 5-HT1 and 5-HT4, are critical to trigger a strong antidepressant response in preventing or treating depressive illness. Therefore, several 5-HT receptor subtypes have been treated as therapeutic targets for developing novel 5-HT receptor antagonists in many clinical applications.
As a global contract research organization, Creative Biolabs worked on a wide range of psychiatric drug discovery and development services for various psychiatric disease types. We utilize unrivaled, proprietary target selection, drug design, study data, product candidate, advanced project lifecycle management, as well as real-time data to ensure the ideal outcomes. Nowadays, we have established an advanced 5-HT receptor antagonist discovery platform which enables us to offer a series of high-quality products for the treatment of a full range of psychiatric diseases. In our company, we have designed and synthesized a panel of compounds that bind to most 5-HT receptor types, such as 5-HT1A, 5-HT1B, and 5-HT7. Furthermore, a panel of assays, including the pharmacokinetic profiling, affinity testing, candidate optimization assay, in vivo functional assays have been used for developing effective 5-HT receptor antagonists in psychiatric disease therapy.
Chief Services
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Design of Potent Selective 5-HT Receptor Antagonists
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Identification of 5-HT Receptor Selective/Potent Antagonists
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In Vitro Viability and Apoptosis Assays
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ADME Properties Analysis of 5-HT Receptor Antagonists
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5-HT Receptor Antagonists Optimization as Drug-Like Molecules
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Pharmacokinetic Characteristics of 5-HT Receptor Antagonists
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In Vitro and In Vivo Efficacy Models
With years of operational experience, Creative Biolabs has built a team of experienced scientists with facilities and processes designed specifically to provide the best-customized 5-HT receptor antagonists to suit the targets of your projects. We are always committed to assisting our clients with the most satisfactory 5-HT receptors-based services. If you have any special needs in our 5-HT receptor antagonist development services or be interested in learning more about our company, please feel free to contact us for more details.
For Research Use Only.
