Creative Biolabs is a leading CRO company of the class of neuroendocrine marker development around the world. We have armed with a robust and standardized platform, aiming to offer the best and convenient neuroendocrine marker development services for our customers worldwide.
Neuroendocrine Abnormalities with Psychiatric Disorders
The study of neuroendocrine abnormalities in major mental illness has been the focus of interest in the past few years. Hormonal changes are frequent in patients with depression, with accumulating evidence supporting a pathophysiologic role in the context of depression. The neuroendocrine window into the brain has been considered a fruitful and promising approach to studying psychiatric disorders, as suggested by studies of some neuroendocrine challenge tests in depression that demonstrate their potential use as biological markers.
Some neuroendocrine abnormalities such as hypersecretion of cortisol and diurnal hypersecretion of growth hormone have been reported in studies of patients suffering from endogenous depression. The disorder of circadian timekeeping seems to characterize acute episodes of major endogenous depression in some patients. Therefore, the detection and characterization of neuroendocrine abnormalities might provide information useful for understanding neurotransmitter dysfunction linked to psychiatric disorders.
Neuroendocrine Marker Development at Creative Biolabs
As a leading CRO company, Creative Biolabs has a robust and standardized platform, aiming to offer the best and most convenient psychiatric disorders-related services. Through the wide range of neuroendocrine marker solutions, Creative Biolabs can help you develop a series of neuroendocrine markers to achieve your specific demands.
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Dexamethasone-Suppression Test (DST)
DST, a measure of cortisol hypersecretion, has become the most studied biological marker and widely used in psychiatry as a laboratory aid for diagnosing some psychiatric disorders such as depression. It has also been associated with suicidal behavior, melancholic and latter atypical features. The use of DST in psychiatric research still has considerable merit, i.e., the differentiating psychotic depression from schizophrenia and serial DST monitoring of depressed patients undergoing drug treatment. The sensitivity of the DST in major depression is limited but is higher in psychotic affective disorders and mixed manic-depressive states. With over ten years of experience, scientists of Creative Biolabs are happy to help resolve any questions you may have about DST.
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Thyrotropin-Releasing Hormone Stimulation Test (TRHST)
Thyroid hormone is involved in brain development and function, and thyroid hormone abnormalities are among the hallmarks of psychiatric disorders. Abnormal blunted responses to thyroid-stimulating hormone (TSH) and thyrotropin-releasing hormone (TRH) stimulation have been found consistently in depressed patients and have been reported in other affective disorders as well. Thus, Creative Biolabs offers a TRH stimulation test alone or in conjunction with other biological tests, which may have diagnostic utility in identifying depression or differentiating manic and depressed subjects from people with schizophrenia.
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Growth Hormone (GH) Challenge Test
Creative Biolabs also provides the GH challenge test, a neuroendocrine marker for some psychiatric disorders, to identify if hGH (human growth hormone) is deficient. Like other laboratory tests, the GH challenge test may help resolve uncertainty in clinical diagnosis and refine current paradigms for psychiatric nosology and diagnosis.
Creative Biolabs is a leading company in developing neuroendocrine markers for psychiatric disorders. Our experienced scientists are available to support our customers in terms of technical expertise in neuroendocrine marker development based on our well-established platform. For more detailed information, please feel free to contact us or directly send us an inquiry.
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