The ability to generate neurons from the reprogramming of non-neural cells that are readily obtainable from living patients and their relatives provides new tools for drug testing and screening in psychiatric disorders. With deep industry experience, Creative Biolabs provides a full range of induced pluripotent stem cells (iPSCs) model development services to satisfy our clients' specific demands.
Importance of iPSC Application in Psychiatric
Neuropsychiatric manifestations often involve higher cognitive processes that are difficult to study in nonhuman models. However, over the last decade, human induced pluripotent stem cell (hiPSC) technology has emerged to advance the study of neuropsychiatric disease and hold significant potential to define pathophysiological mechanisms and identify potential therapeutic targets. Stem cells possess both self-renewal and pluripotent capabilities. Patient-derived hiPSCs provide an alternative to primary human brain tissue which can be difficult to obtain and which may lack cell types that can be critical for disease pathology, solving a previously intractable constraint in the study of neuropsychiatric disorders.
iPSC Application in Psychotropic Disorders
SCZD is an ideal disorder to model through stem cell approaches due to its heterogeneous, complex genetics that is hard to recapitulate in animal models. In one of the first illustrations of the hiPSC approach in neuropsychiatry, researchers directly reprogrammed fibroblasts from SCZD patients into hiPSCs and differentiated these into neurons. Neuronal connectivity, neurite outgrowth, and differential gene expression were assayed in disease-specific hiPSC neurons. A recombinant labeled form of the neurotropic rabies virus was used as a transsynaptic tracer to show decreased neuronal connectivity in SCZD hiPSC neurons, in addition to decreased neurite number and decreased levels of the excitatory postsynaptic protein PSD95. In addition, gene expression profiles of SCZD hiPSC neurons identified altered expression of many components of the cAMP and WNT signaling pathways.
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Autism spectrum disorder (ASD)
ASD is a neurodevelopmental disorder characterized by persistent deficits in social communication across multiple contexts and restricted, repetitive patterns of behavior, with or without intellectual disability or language impairment. hiPSC models can effectively recapitulate the heterogeneous genetic background typical of nonsyndromic ASD that would be difficult or impossible to generate/study in traditional animal models. In a recent study, NPCs and neurons were generated from hiPSC lines derived from nonsyndromic ASD patients with comorbid macrocephaly. NPCs differentiated from ASD cell lines displayed increased proliferation associated with dysregulation of a novel transcriptional cascade, indicating a potential mechanism for the brain overgrowth observed in the patients from which these cells were derived.
Services at Creative Biolabs
Focus on psychotropic drug development for years, Creative Biolabs has thrown in a great deal of manpower, materials, and financial resource to reaches cellular model development for psychiatric disorders. With extensive experience accumulated from practice, we are capable of providing reliable iPSCs model development services to our clients. Our platform with the latest technologies, mature technicians, and professional specialists will assure the quality of the relative services.
Advantages
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Facility: One-stop worry-free services
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Reliable: Extensive industry experience
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Professional: Excellent technology platform with Ph.D. level specialists
With the development of iPSCs application, it has shown grown importance in psychiatry research. Based on a wealth of relative knowledge and industry experience, Creative Biolabs offers quality-assured iPSCs model development and customize services to global clients. If you are interested in cellular model development for psychiatric disorders, please feel free to contact us for more information.
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