Creative Biolabs provides state-of-the-art equipment and the comprehensive analysis and expertise necessary to help researchers with target validation and qualification for psychiatric disorders. Characterizing the relationship between pharmacokinetics (PK) and pharmacodynamics (PD) is an important tool in the discovery and development of new drugs for the treatment of psychiatric disease. We offer high-quality PK/PD preclinical experiments and phase I/II clinical studies to support the translational research for psychiatric disorders. We are more than happy to share our experience and help our customers with combined measures (PK/PD) in psychotropic drug development.
Importance of PK/PD Study for Drug Development
The PK and PD properties of a drug need to be well defined to make informed decisions regarding appropriate dosing recommendations. The regulatory authorities also clearly recommend those investigations of the PK/PD relationship are included in drug development programs. The major objective of early drug development is to select promising compounds and to identify potentially effective and safe doses and dosing regimens. Integration of the results of PK/PD in early development helps with drug selection and guides the creation of an efficient clinical development strategy.
Fig.1 The iterative process of PK/PD modeling in drug discovery. (Tuntland, 2014)
Translational PK/PD Study at Creative Biolabs
Creative Biolabs specializes in implementing PK/PD strategies in the early research phases of psychotropic drug discovery projects to enable a successful transition to drug development. Effective PK/PD study design, analysis, and interpretation can help researchers elucidate the relationship between PK and PD, understand the mechanism of drug action, and identify PK properties for further improvement and optimal compound design. Additionally, PK/PD modeling can help reduce the number of in vivo animal studies and improve the translation of findings from preclinical species into the clinical setting. Creative Biolabs has organized a staff of outstanding scientists who have engaged in translational research for psychiatric disorders. We offer comprehensive project support for translational research for psychiatric disorders, which includes:
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PK/PD preclinical experiments
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PK/PD Phase I/II clinical studies
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Analysis of potential psychotropic drugs, including drug metabolites, physiological metabolites, and biomarkers, by HPLC and LC/MS
With industry-leading expertise and state-of-the-art software, our modeling experts provide high-quality PK/PD modeling service, which can lead to fewer study failures and a smaller number of studies needed for registration. Key advantages of our PK/PD modeling service include but are not limited to:
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Cutting-edge model development
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Design of studies and interpretation of results
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PK/PD modeling for biologics and antibodies
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Extensive model evaluation
Creative Biolabs offers accurate and effective solutions in the PK/PD study for researchers who are committed to psychotropic drug development. For more detailed information, please feel free to contact us or directly send us an inquiry.
Reference
- Tuntland, T.; et al. Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research. Frontiers in pharmacology. 2014, 5:174. Distributed under Open Access license CC BY 3.0, without modification.
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